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NOT YET RECRUITING
NCT07702890
PHASE1/PHASE2

A Three-part First-in-human Trial to Assess Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of GUB-UCN2 in Healthy Lean and Obese Participants and Participants With T2D

Sponsor: Gubra A/S

View on ClinicalTrials.gov

Summary

The trial will enroll healthy volunteers and individuals living with obesity, with and without Type 2 Diabetes. The study, with a treatment period of up to 16 weeks in selected cohorts, will investigate GUB-UCN2 as both a standalone therapy and on top of standard of care for obesity

Official title: A Three-part First-in-human, Single and Multiple Ascending and Repeated Dose Trial to Assess the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Subcutaneous GUB-UCN2 in Healthy Lean and Obese Participants and in Participants With Type 2 Diabetes

Key Details

Gender

All

Age Range

18 Years - 75 Years

Study Type

INTERVENTIONAL

Enrollment

188

Start Date

2026-07

Completion Date

2028-12

Last Updated

2026-07-14

Healthy Volunteers

Yes

Interventions

DRUG

GUB-UCN2

GUB-UCN2 will be administered subcutaneously

DRUG

Placebo

Placebo will be administered subcutaneously