Clinical Research Directory
Browse clinical research sites, groups, and studies.
Early Kidney Injury Biomarkers in Gynecologic Laparoscopic Surgery
Sponsor: Medipol University
Summary
This prospective observational study aims to evaluate early subclinical acute kidney injury associated with pneumoperitoneum and Trendelenburg positioning during gynecological laparoscopic surgery. Urinary neutrophil gelatinase-associated lipocalin (NGAL) and kidney injury molecule-1 (KIM-1) levels will be measured and normalized to urinary creatinine. Biomarker changes will be compared between patients undergoing surgery in 30° and 45° Trendelenburg positions. The study seeks to determine whether these biomarkers can detect early renal injury before clinically significant changes in serum creatinine occur.
Official title: Comparative Analysis of Urinary NGAL and KIM-1 Levels in Predicting Subclinical Acute Kidney Injury Secondary to Pneumoperitoneum and Deep Trendelenburg Position in Gynecological Laparoscopic Surgery
Key Details
Gender
FEMALE
Age Range
18 Years - Any
Study Type
OBSERVATIONAL
Enrollment
50
Start Date
2026-08-01
Completion Date
2027-03-01
Last Updated
2026-07-15
Healthy Volunteers
No
Interventions
Pneumoperitoneum and Trendelenburg Positioning
Standard intraoperative carbon dioxide pneumoperitoneum combined with either 30° or 45° Trendelenburg positioning during laparoscopic surgery
Locations (1)
Medipol Mega University Hospital
Istanbul, Istanbul, Turkey (Türkiye)