Clinical Research Directory

Inclusion Criteria: * 1\. Ages 18-70 * 2\. Hp infection treatment failed ≥4 times with guidelines-recommended therapies * 3\. Patients with early gastric cancer, peptic ulcer, gastric MALT lymphoma, atrophic gastritis and other diseases requiring the eradication of Hp. Exclusion Criteria: * 1\. Antibiotics and bismuth were taken within 4 weeks before this treatment; Or had taken PPI, H2 receptor antagonist, P-CAB within 2 weeks prior to treatment; * 2\. Pregnant or lactating women; * 3\. Those who are allergic to the investigational drugs used in this test or have contraindications; * 4\. Participated in other drug trials within 3 months before the treatment of this trial; * 5\. There are other serious diseases that affect the evaluation of this study at the same time, or they cannot correctly express their own complaints and cannot cooperate; * 6\. Subjects with dysphagia; * 7\. Patients with malignant tumors, serious concomitant diseases, severe ulcer bleeding or perforation; * 8\. Patients judged by the investigator to be unsuitable for clinical trials. * 9\. Those who do not want to sign the informed consent for the study.