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Resin Infiltration Versus Microabrasion With CPP-ACP for Fluorotic White Spot Lesions
Sponsor: Hue University of Medicine and Pharmacy
Summary
Dental fluorosis can cause visible chalky-white spots on the front teeth. These white spot lesions may affect dental appearance even when the tooth surface is intact. This randomized clinical trial compared two minimally invasive approaches for masking fluorotic white spot lesions on permanent anterior teeth. Eligible teeth were randomly assigned to receive either resin infiltration or enamel microabrasion followed by application of casein phosphopeptide-amorphous calcium phosphate (CPP-ACP). The main outcomes were the color difference between the white spot lesion and the surrounding sound enamel and the proportion of the visible tooth surface occupied by the lesion. These outcomes were evaluated from standardized clinical photographs before treatment, after treatment, and during follow-up through 6 months.
Official title: Resin Infiltration Versus Microabrasion Combined With CPP-ACP for Masking Fluorotic Anterior White Spot Lesions: A 6-Month Randomized Controlled Clinical Trial
Key Details
Gender
All
Age Range
Any - Any
Study Type
INTERVENTIONAL
Enrollment
42
Start Date
2023-06-01
Completion Date
2025-06-30
Last Updated
2026-07-15
Healthy Volunteers
No
Conditions
Interventions
Resin infiltration
After tooth cleaning and rubber-dam isolation, 15% hydrochloric acid was applied to the fluorotic white spot lesion for 120 seconds, rinsed for 30 seconds, and air-dried. Ethanol was applied for 30 seconds to assess lesion masking, and the etching step was repeated if the lesion remained visible. A low-viscosity resin infiltrant was applied for 180 seconds, excess material was removed, and the surface was light-cured for 40 seconds. A second application was performed for 60 seconds and light-cured for an additional 40 seconds.
Enamel Microabrasion Plus CPP-ACP
After tooth cleaning and rubber-dam isolation, an enamel microabrasion material containing 6.6% hydrochloric acid and silicon carbide particles was applied to the labial enamel surface and polished with a rubber cup at approximately 500 rpm for 60 seconds. The surface was rinsed, and the procedure was repeated for five cycles. CPP-ACP paste was then applied to the treated enamel surface for 5 minutes.
Locations (1)
Faculty of Odonto-Stomatology, University of Medicine and Pharmacy, Hue University
Huế, Vietnam