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More Than Just X-Rays - Imaging of Chemotherapy-induced Morphological and Functional Cardiovascular and Lung Changes After Childhood ALL and Other Cancers - a Monocentric Late Effects Study (MaximALL)
Sponsor: University of Erlangen-Nürnberg Medical School
Summary
In this study, we investigate the cardiopulmonary health of survivors who underwent cancer treatment for acute lymphoblastic leukemia (ALL) or lymphoma during childhood, compared with healthy controls. Modern imaging techniques (MRI, MSOT, and echocardiography) as well as questionnaires assessing cardiopulmonary and mental health are used.
Official title: "MaximALL" More Than Just X-Rays - Imaging of Chemotherapy-induced Morphological and Functional Cardiovascular and Lung Changes After Childhood ALL and Other Cancers - a Monocentric Late Effects Study (MaximALL)
Key Details
Gender
All
Age Range
3 Years - Any
Study Type
INTERVENTIONAL
Enrollment
180
Start Date
2026-07-14
Completion Date
2028-10-31
Last Updated
2026-07-15
Healthy Volunteers
Yes
Conditions
Interventions
QOL assessment, Neuropsychological
QoL assessment by EORTC SURV100, PPR
Spirometry
During this non-invasive test, the subject must breathe against resistance through a mouthpiece.
DLCO measurement
DLCO measurement is a non-invasive pulmonary function test for Pulmonary Diffusion Capacity.
Echocardioraphy
Echocardiography with strain-rate imaging.
MRI
LF-MRI for detection of morphological and functional changes in the lung and heart.
Clinical parameters
Recording patient information (Age, Gender, Weight and height, Ethnicity, current medication, measurement of blood pressure and blood oxygen saturation.
Blood samples
Blood samples for further molecular testing regarding epigenetic aging markers and telomere biology parameters.
MSOT
multispectral optoacoustic tomography of musculus gastrocnemius bilaterally for screening of PAD
Locations (1)
Department of Pediatrics and Adolescent Medicine
Erlangen, Germany