Clinical Research Directory

Inclusion Criteria: 1. Age ≥ 18 years and any of criteria 2-3 2. AF with a CHA2DS2-VA score ≥2 and a HAS-BLED score ≥3 or other clinically significant bleeding condition and ongoing OAC treatment 3. AF with a CHA2DS2-VA score ≥2 but deemed unfit for OAC by responsible physician due to clinical contraindications (e.g. amyloid angiopathy, previous intracranial haemorrhage or severe gastrointestinal bleeding). Exclusion Criteria: 1. Clinical frailty score ≥5 2. Indication for OAC other than AF 3. Indication for dual antiplatelet therapy, if OAC is discontinued 4. Previous open-heart surgery 5. Present indication for cardiac surgery 6. Present indication for ablation for atrial fibrillation 7. Previous radiation therapy of the chest, due to malignancy 8. Previous pericarditis or myocarditis 9. Previous surgery including access to the left pleural space 10. Documented FEV1\<70% or other significant pulmonary disease (including but not restricted to fibrosis, pulmonary post-covid syndrome, cystic fibrosis) 11. Ongoing treatment with corticosteroids or previous treatment for more than 3 consecutive months. 12. Allergy to contrast media 13. Patient already included in another interventional clinical trial 14. Patient listed abroad, which would render them to be lost to follow-up after discharge 15. Patient does not understand study information given in the local language or, for other reasons, is deemed unfit to participate according to the investigators