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Outcome of Patients With Severe Mental Illness in the Intensive Care Unit
Sponsor: Centre Hospitalier Intercommunal de Toulon La Seyne sur Mer
Summary
Severe mental illnesses (SMIs), such as major depression, schizophrenia, and bipolar disorder, carry a significant prevalence among patients admitted to the intensive care unit (ICU), estimated at an average of 19%. Evidence indicates that ICU hospitalization is associated with a poorer prognosis regarding mental health and morbi-mortality compared to hospitalization in conventional wards. Despite this recognized vulnerability, available data remain limited and are often derived from retrospective studies with conflicting results. Some studies have shown that SMIs impact neither critical care nor long-term mortality. Conversely, other research has reported higher hospital mortality, an increase in complications (such as mechanical ventilation and prolonged length of stay), and unfavorable functional outcomes. Regarding specific conditions like septic shock, unexpected findings have been observed, with certain SMIs appearing to be associated with reduced 90-day mortality compared to a matched control population. Patients with SMIs thus represent a vulnerable population whose management in the ICU setting may pose specific challenges. This prospective, multicenter study aims to evaluate mortality and identify predictive factors of mortality among patients with SMIs managed in French ICUs.
Official title: Prospective Multicenter Study Assessing the Outcome of Patients With Severe Mental Illness Admitted to Intensive Care Units
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
OBSERVATIONAL
Enrollment
2000
Start Date
2026-09
Completion Date
2031-09
Last Updated
2026-07-15
Healthy Volunteers
No
Interventions
Observational follow-up
Standard care with a 12-month follow-up period to assess long-term outcomes.
Locations (30)
Centre Hospitalier Universitaire de Nice
Nice, Alpes-Maritimes, France
Groupe Hospitalier Littoral Atlantique
La Rochelle, Charente-Maritime, France
Hôpital privé Claude Galien
Quincy-sous-Sénart, Essonne, France
CHU Ambroise Paré AP-HP
Boulogne-Billancourt, Hauts-de-Seine, France
Centre Hospitalier Universitaire de Rennes
Rennes, Ille-et-Vilaine, France
Centre Hospitalier Simone Veil
Blois, Loir-et-Cher, France
Centre Hospitalier de Cahors
Cahors, Lot, France
Centre Hospitalier Bretagne Atlantique de Vannes
Vannes, Morbihan, France
CHU de Lille - Hôpital Roger Salengro
Lille, Nord, France
Hôpital Saint Louis (AP-HP)
Paris, Paris, France
Hôpital La Pitié Salpêtrière
Paris, Paris, France
Hôpital La Pitié Salpêtrière
Paris, Paris, France
Hôpital Bichat
Paris, Paris, France
Hôpital Tenon (AP-HP)
Paris, Paris, France
Hôpital Saint Joseph
Paris, Paris, France
CHU de Clermont-Ferrand
Clermont-Ferrand, Puy-de-Dôme, France
Grand Hôpital de l'Est Francilien - Site de Jossigny
Jossigny, Seine-et-Marne, France
Grand Hôpital de l'Est Francilien - Site de Meaux
Meaux, Seine-et-Marne, France
Groupe Hospitalier Sud Ile de France
Melun, Seine-et-Marne, France
Hôpital Nord Franche Comté
Trévenans, Territoire de Belfort, France
Centre Hospitalier Intercommunal Toulon La Seyne sur Mer
Toulon, Var, France
Hôpital National d'Instruction des Armées de Sainte Anne
Toulon, Var, France
Centre Hospitalier de Versailles
Le Chesnay, Yvelines, France
Centre Hospitalier d'Agen-Nerac
Agen, France
Centre Hospitalier d'Arles
Arles, France
Centre Hospitalier Intercommunal de Compiègne-Noyon
Compiègne, France
Centre Hospitalier de Dieppe
Dieppe, France
Hôpital Européen Marseille
Marseille, France
Hôpital Privé Jacques Cartier - Ramsay Santé
Massy, France
Groupe Hospitalier Nord Essonne - Site Paris-Saclay
Orsay, France