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Naproxen and Lidocaine Gel Combination for Rib Fracture
Sponsor: Ankara City Hospital Bilkent
Summary
This study evaluates whether adding a topical gel containing naproxen and lidocaine to routine intravenous analgesic treatment improves pain relief in adults with isolated traumatic rib fractures presenting to the emergency department. Participants are randomly allocated to receive either standard intravenous dexketoprofen alone or dexketoprofen combined with topical naproxen-lidocaine gel. Pain intensity is measured repeatedly during the first hour after treatment using the Numerical Rating Scale (NRS). The study also examines the need for additional rescue analgesia and monitors treatment-related adverse events to determine the effectiveness and safety of this multimodal analgesic strategy.
Official title: Analgesic Efficacy of a Naproxen and Lidocaine Gel Combination in Patients With Traumatic Rib Fractures: A Randomized Controlled Trial
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
110
Start Date
2024-01-01
Completion Date
2024-07-02
Last Updated
2026-07-20
Healthy Volunteers
No
Interventions
A gel combination containing 10% naproxen and 5% lidocaine
Approximately 10 grams of a gel combination containing 10% naproxen and 5% lidocaine to the rib fracture site, covering both the upper and lower ribs
Dexketoprofen trometamol 50 mg IV
Dexketoprofen at a dose of 50 mg, dissolved in 150 ml of 0.9% NaCl solution and administered intravenously via rapid infusion over 15 minutes
Locations (1)
Ankara Bilkent City Hospital; Department of Emergency Medicine
Ankara, Çankaya, Turkey (Türkiye)