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E.N.D.E.A.V.O.R.: An Exemestane Needed Dose Efficacy and Verification as an Ovulation Induction Regimen Study
Sponsor: University of North Carolina, Chapel Hill
Summary
The goal of this clinical trial is to learn if study drug exemestane will increase chances of ovulation for patients with polyendocrine metabolic ovarian syndrome (PMOS, formerly called polycystic ovary syndrome (PCOS)). It will also learn about side effects of study drug exemestane in this study population. The main questions it aims to answer are: Does exemestane lead to ovulation for patients with polyendocrine metabolic ovarian syndrome (PMOS- formerly called PCOS)? Researchers will compare exemestane to a placebo (a look-alike substance that contains no drug) to see if exemestane helps PMOS patients ovulate. Participants will: Take exemestane or a placebo every day for 5-10 days Visit the clinic three times for ultrasounds, labs, and to answer questions about side effects. If they become pregnant during this study, they will tell us how their pregnancy went after the study via a registry online.
Key Details
Gender
FEMALE
Age Range
18 Years - 40 Years
Study Type
INTERVENTIONAL
Enrollment
40
Start Date
2026-08
Completion Date
2030-01
Last Updated
2026-07-15
Healthy Volunteers
No
Conditions
Interventions
Exemestane 25 MG
Experimental Drug
Placebo
Placebo drug that patients in placebo arm will take
Exemestane 50 MG
One study arm with take two tablets for 5 days (50mg per day)
Locations (1)
UNC Fertility
Raleigh, North Carolina, United States