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Plasma Exchange in Children With Severe Sepsis and Septic Shock
Sponsor: Menoufia University
Summary
The aim of the study will be to to evaluate whether therapeutic plasma exchange (TPE) reduces mortality in critically ill children with severe sepsis or septic shock compared to the standard care of sepsis alone. The study population will be divided into two groups, the first group will receive standard sepsis management plus therapeutic plasma exchange and the second one will receive the standard sepsis management alone . Then we will assess the effect of TPE on : Severity of organ dysfunction (pSOFA score) , duration of vasopressor support , length of PICU stay, time to hemodynamic stabilization , and on inflammatory and coagulation biomarkers
Official title: Therapeutic Plasma Exchange in Children With Severe Sepsis and Septic Shock: A Randomized Controlled Clinical Trial
Key Details
Gender
All
Age Range
1 Month - 18 Years
Study Type
INTERVENTIONAL
Enrollment
22
Start Date
2026-08-01
Completion Date
2027-03-31
Last Updated
2026-10-07
Healthy Volunteers
No
Conditions
Interventions
Plasma exchange (PE)
Therapeutic plasma exchange to the intervention Group (plasma exchange Arm) that will receive also the standard sepsis management.
Locations (1)
Menoufia university hospital, Pediatric intensive care unit
Shibīn al Kawm, Menoufia Governorate, Egypt