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Heart Rate Variability and Medication Adherence in Resistant Hypertension
Sponsor: Nemocnice AGEL Trinec-Podlesi a.s.
Summary
This single-center, cross-sectional observational study examines the relationship between adherence to antihypertensive therapy - verified objectively by therapeutic drug monitoring (TDM) - and heart rate variability (HRV) in patients with resistant hypertension. Patients are recruited opportunistically, in a nurse-led manner, in a one-day-care cardiology unit, and undergo a single examination: a short-term HRV recording (Polar H10), a single blood draw for antihypertensive drug levels, office blood pressure, and self-completed questionnaires. There is no follow-up.
Official title: Eart Rate Variability, Medication Adherence, and Blood Pressure Control in Resistant Hypertension: A Cross-Sectional Study
Key Details
Gender
All
Age Range
18 Years - 75 Years
Study Type
OBSERVATIONAL
Enrollment
150
Start Date
2026-07-20
Completion Date
2027-12-31
Last Updated
2026-07-16
Healthy Volunteers
No
Interventions
Heart rate variability recording (Polar H10) ·
Short-term (10-15 min) seated HRV; time-domain (SDNN, RMSSD, pNN50) and frequency-domain (LF, HF, LF/HF) parameters.
Therapeutic drug monitoring (antihypertensive drug levels)
Single blood draw measuring antihypertensive drug levels; defines adherent vs non-adherent status.
Questionnaires (MARS-CZ, PHQ-9, SF-36, IPAQ)
Self-completed instruments assessing medication adherence, mood, quality of life, and physical activity.
Locations (1)
Nemocnice AGEL Třinec-Podlesí a.s.
Třinec, Moravian-Silesian Region, Czechia