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Neural Sensitisation and Neuropsychological Alterations in Painful Chronic Pancreatitis
Sponsor: Asian Institute of Gastroenterology, India
Summary
Chronic pancreatitis (CP) is a progressive inflammatory disease in which chronic abdominal pain affects up to 80% of patients and remains difficult to manage despite treatment of pancreatic pathology. Increasing evidence suggests that persistent pain is not solely driven by peripheral pancreatic abnormalities but also by central sensitization, involving maladaptive changes in central nervous system pain-processing pathways. While altered brain connectivity and neurochemical changes have been demonstrated in other chronic pain disorders, these mechanisms remain poorly characterized in CP. This study aims to integrate clinical phenotyping with blood-based metabolite profiling and advanced neuroimaging, including resting-state functional MRI and magnetic resonance spectroscopy, to investigate the relationship between central sensitization, brain dysfunction, and neuropsychological alterations. The findings may identify objective neurobiological markers of pain and facilitate the development of mechanism-based, personalized treatment strategies for patients with chronic pancreatitis.
Official title: EVALUATION OF THE RELATIONSHIP BETWEEN NEURAL SENSITISATION AND NEUROPSYCHOLOGICAL ALTERATIONS IN PATIENTS WITH PAINFUL CHRONIC PANCREATITIS
Key Details
Gender
All
Age Range
18 Years - 60 Years
Study Type
OBSERVATIONAL
Enrollment
200
Start Date
2026-01-06
Completion Date
2026-11-30
Last Updated
2026-07-16
Healthy Volunteers
Yes
Conditions
Interventions
Comprehensive Neuropsychological Assessment
A comprehensive set of clinical and neurological tests to be performed on all participants. This includes validated mental state and sleep evaluations (HADS, PSQI), quality-of-life assessments (EORTC QLQ-C30 + PAN28),and quantitative sensory testing (P-QST)
Resting-State Functional MRI (fMRI)
An advanced neuroimaging scan performed on all participants to assess resting-state functional connectivity within key pain-processing networks.
Magnetic Resonance Spectroscopy (MRS)
A neuroimaging technique performed on all participants to quantify brain metabolites in key brain regions.
Blood-Based Metabolite Profiling
Blood samples will be collected from all participants to quantify metabolomic signatures and to identify potential correlates with pain phenotypes in chronic pancreatitis.
Locations (1)
Asian Institute of Gastroenterology
Hyderabad, Telangana, India