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Plasma Exchange in Pediatric Autoimmune Encephalitis
Sponsor: Menoufia University
Summary
The aim of the study will be to compare the efficacy of daily plasma exchange (PLEX) versus alternate-day PLEX in achieving a favorable functional outcome in children with autoimmune encephalitis. The study population will be divided into two groups, the first group will perform PLEX on consecutive days and the second one will perform it every other day. Then, A Favorable functional outcome measure defined as modified Rankin Scale (mRS) score ≤ 2. The mRS will be assessed by a blinded assessor at the end of the sessions to determine which method has superior efficacy in treatment of autoimmune encephalitis.
Official title: Daily Versus Alternate-Day Plasma Exchange in Pediatric Autoimmune Encephalitis: A Randomized Controlled Trial
Key Details
Gender
All
Age Range
1 Month - 18 Years
Study Type
INTERVENTIONAL
Enrollment
22
Start Date
2026-08-01
Completion Date
2027-03-31
Last Updated
2026-07-16
Healthy Volunteers
No
Conditions
Interventions
Plasma exchange (PE)
Plasma exchange (PE) sessions to be done daily for Arm A
Plasma exchange (PE)
Plasma exchange (PE) sessions to be done on every other day for Arm B
Locations (1)
Menoufia university hospital, Pediatric intensive care unit
Shibīn al Kawm, Menoufia Governorate, Egypt