Clinical Research Directory
Browse clinical research sites, groups, and studies.
Optimizing Hydroxyurea Therapy in Children With Sickle Cell Anemia In Malaria Endemic Areas: The NOHARM Maximum Tolerated Dose (MTD) Study
Sponsor: Children's Hospital Medical Center, Cincinnati
Summary
NOHARM MTD is an extension of a previous study for children with Sickle Cell Anemia (SCA) who were enrolled in the NOHARM study. All children enrolled in NOHARM received hydroxyurea treatment at a fixed daily dose of 20 mg/kg/day. This dose was selected as a likely safe dose, but does not escalate hydroxyurea to maximum tolerated dose "MTD" as is commonly done in the US. Without this information, we cannot know whether hydroxyurea treatment at the MTD would be feasible (since it requires closer monitoring to avoid hematological toxicities), safe (since adverse events may be greater with MTD, risk of malaria may be altered by MTD, and risk of infections as a result of neutropenia could also be greater with MTD) or beneficial (MTD is associated with higher hemoglobin and fetal hemoglobin concentration).
Key Details
Gender
All
Age Range
11 Years - 18 Years
Study Type
INTERVENTIONAL
Enrollment
250
Start Date
2026-05-13
Completion Date
2032-11-30
Last Updated
2026-07-16
Healthy Volunteers
No
Interventions
hydroxycarbamide
Hydroxyurea at optimized dose
Locations (1)
Mulago Hospital Sickle Cell Clinic
Kampala, Uganda