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Sustained Release Oral Formulation For Treatment Of Parkinsons Disease
Sponsor: University of Minnesota
Summary
LD/CD (medications to treat Parkinson's disease) will be delivered using an assembly of nested sachets made of permeable material. The assembly is placed in the oral/buccal cavity (between cheek and gum of lower jaw) and delivers continuous release of CD and LD for both transmucosal and gastrointestinal absorption. The combination of CD/LD in the inner sachet varies from that in the outer sachet. This allows for sequential release of CD and then LD to mimic a CD pretreatment method which is known to increase LD absorption and prolong its half-life.
Key Details
Gender
All
Age Range
18 Years - 65 Years
Study Type
INTERVENTIONAL
Enrollment
32
Start Date
2026-06-30
Completion Date
2027-06-30
Last Updated
2026-07-16
Healthy Volunteers
Yes
Conditions
Interventions
Formulation A
outer sachet 100 mg CD/0mg LD and inner sachet 0mg CD /400mg LD
Formulation B
outer sachet 150mg CD/0mg LD and inner sachet 600mg LD
Formulation C
outer sachet 200mg CD/0mg LD and inner sachet 800mg LD
Locations (1)
University of Minnesota
Minneapolis, Minnesota, United States