Clinical Research Directory

Inclusion Criteria: 1. patients with moderate-to-severe non-cancerous chronic pain (Age: 18\~55 years, NRS score≥4); 2. Body Weight: Male≥50.0kg, Female≥45.0kg; 19.0 ≤BMI≤ 26.0; 3. There were no abnormalities in clinically significant physical examination, vital signs, 12-lead electrocardiogram, chest x-ray, abdominal B-ultrasound, laboratory tests; Exclusion Criteria: 1. Allergy or Drug hypersensitivity; 2. Clinically significant Medical History; 3. History of anesthesia accident, history of serious adverse reactions of anesthesia, or family history of anesthesia accidents, or contraindications to general anesthesia; 4. Dyspnoea or suspected difficult airway, or predicting difficult endotracheal intubation; 5. History of bronchial asthma, chronic obstructive pulmonary disease, sleep apnea syndrome; 6. History of adrenal insufficiency or adrenal tumor or hereditary heme biosynthesis disorder or hereditary acute porphyria; 7. History of any surgery within 3 months; 8. History of any Medication within 14 days; 9. History of any inducers or inhibitors of CYP3A4 or CYP2C19 enzymes within 30 days; 10. History of any clinical study within 3 months; 11. History of any vaccine within 1 month; 12. History of any drug abuse; 13. Needle sickness, Hematosickness; 14. Massive blood loss (\> 400 mL) in the past 3 months; 15. Female volunteers are pregnant or lactating; 16. History of unprotected sex within 2 weeks; 17. Heavy smoker ( more than 5 cigarettes/day) within 3 months; 18. History of alcohol abuse,or heavy alcohol intake (more than 14 units a week) within 6 months; 19. Heavy caffeine intake; 20. History of grapefruit, xanthine-rich foods intake within 48 hours; 21. Positive alcohol test; 22. Positive nicotine test; 23. Positive drugs of abuse test result.