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Remineralizing Effect of Nano-eggshell, Casein Phosphopeptide Amorphous Calcium Phosphate (CPP-ACP), and Sodium Fluoride on Initial Enamel Caries
Sponsor: Mansoura University
Summary
This randomized controlled clinical trial aims to evaluate and compare the remineralizing effect of nano-eggshell varnish, CPP-ACP paste (GC Tooth Mousse), and sodium fluoride varnish on initial enamel caries among adolescents aged 15-20 years. Participants will be randomly allocated into three groups. Remineralization and caries activity will be assessed using DIAGNOdent readings, International Caries Classification and Management System (ICCMS) criteria, and the decayed, missed, and filled surfaces (DMFS) index over a 12-month follow-up period.
Official title: Remineralizing Effect of Nano-eggshell, Casein Phosphopeptide Amorphous Calcium Phosphate (CPP-ACP), and Sodium Fluoride on Initial Enamel Caries: Randomized Controlled Trial
Key Details
Gender
All
Age Range
15 Years - 20 Years
Study Type
INTERVENTIONAL
Enrollment
90
Start Date
2025-12-20
Completion Date
2026-12-20
Last Updated
2026-07-17
Healthy Volunteers
No
Conditions
Interventions
nano-eggshell varnish
Nano-eggshell varnish is applied topically to tooth surfaces every 3 months, according to manufacturer instructions, to promote the remineralization of initial enamel caries.
Casein Phosphopeptide-Amorphous Calcium Phosphate (CPP-ACP)Dental Paste
Casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) paste was applied daily by participants after tooth brushing at bedtime and left on teeth for at least 3 minutes before rinsing.
Sodium Fluoride Varnish (5%)
5% sodium fluoride varnish is applied topically every 3 months according to manufacturer instructions as a controlled remineralizing agent.
Locations (1)
Faculty of Dentistry, Mansoura University
Al Mansurah, Egypt