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Can Two Dietary Interventions Maintain Weight Loss for 12 Months After GLP-1 Therapy in Adults With Overweight/Obesity?
Sponsor: Knut Mai
Summary
So far, treatment with semaglutide (Wegovy) for therapy of obesity demonstrates substantial effects. However, most patients do not desire life-long pharmaceutical therapy or discontinue this treatment regime. This is accompanied by rapid weight regain. Moreover, numerous patients are open to an intermittent therapy. This trial aims to investigate whether two diet interventions can keep weight stable after weight loss with semaglutide in people with obesity or overweight.
Official title: DIETary Strategies to stabiLize Incretin-based Weight Loss in Obesity Management
Key Details
Gender
All
Age Range
18 Years - 70 Years
Study Type
INTERVENTIONAL
Enrollment
292
Start Date
2027-03
Completion Date
2030-04
Last Updated
2026-07-20
Healthy Volunteers
No
Interventions
NutriAct plus
Dietary pattern, vegetarian version of the NutriAct pattern
Rescue VLCD
Very low calorie diet as full meal replacement over 28 days in case of weight regain