Clinical Research Directory
Browse clinical research sites, groups, and studies.
Exercise and PPARGC1A rs8192678 in Older Adults With Type 2 Diabetes and Cognitive Impairment
Sponsor: Harbin Sport University
Summary
This completed single-arm interventional study evaluated changes in metabolic control, cognitive function, and health-related physical fitness following a 12-week combined aerobic and resistance exercise program in older adults with type 2 diabetes mellitus and cognitive impairment. The study also explored whether the magnitude of response to exercise differed according to PPARGC1A rs8192678 genotype. A total of 75 participants were genotyped, and 45 participants were included in a balanced genotype-stratified cohort, consisting of 15 participants with the CC genotype, 15 with the CT genotype, and 15 with the TT genotype. All participants received the same exercise intervention and were assessed at baseline and at Week 12.
Official title: Association Between PPARGC1A rs8192678 Polymorphism and the Effects of a 12-Week Combined Aerobic and Resistance Exercise Intervention in Older Adults With Type 2 Diabetes Mellitus and Cognitive Impairment
Key Details
Gender
All
Age Range
65 Years - 79 Years
Study Type
INTERVENTIONAL
Enrollment
45
Start Date
2025-03-01
Completion Date
2025-06-01
Last Updated
2026-07-17
Healthy Volunteers
No
Interventions
Combined aerobic and resistance exercise
A 12-week combined exercise program including aerobics and elastic-band resistance training. Aerobic exercise was performed four times per week, with intensity progressing from 50%-60% HRmax during weeks 1-6 to 60%-70% HRmax during weeks 7-12. Resistance exercise was performed twice per week using elastic bands, with intensity progressing from 40%-50% 1RM during weeks 1-6 to 50%-60% 1RM during weeks 7-12. Exercise duration gradually increased from 20 minutes to 40 minutes.
Locations (1)
Harbin Sport University
Harbin, Heilongjiang, China