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Effects of Acute Ketone Supplementation on the Brain
Sponsor: Christopher Crabtree
Summary
The purpose of this study is to determine how a ketone ester supplement affects brain function, brain blood flow, and brain metabolism in healthy middle-aged and older adults. Ketones are naturally produced by the body during periods of fasting or carbohydrate restriction and serve as an alternative fuel source for the brain. Researchers are interested in whether increasing blood ketone levels through supplementation can alter brain activity and blood flow in ways that may support healthy brain function. Participants will consume a ketone ester supplement and a placebo in separate study visits. Brain imaging, blood measurements, and cognitive testing will be used to evaluate the effects of each intervention. Findings from this study will help researchers better understand how ketones influence the healthy aging brain and may provide preliminary data for future studies in populations at risk for cognitive decline.
Official title: Effects of Acute Ketone Supplementation on the Brain [KETO-BRAIN]
Key Details
Gender
All
Age Range
45 Years - 65 Years
Study Type
INTERVENTIONAL
Enrollment
24
Start Date
2026-06-15
Completion Date
2029-12
Last Updated
2026-07-17
Healthy Volunteers
Yes
Conditions
Interventions
Ketone Ester Drink
The ketone ester beverage contains 25 g of C8 Diester emulsified in a matrix of water, whey protein concentrate, modified gum acacia, natural and artificial flavors and cocoa powder. It contains 210 kcal, 0.5 g fat, 2 g carbohydrates, and 2 g protein. Dose consumed is 50 g, 2 times per day for 2 days. The placebo (PL) will be calorie and volume matched to the KE and be formulated with standard dietary ingredients.
Placebo
The placebo drink will be calorie and volume matched to the KE and be formulated with standard dietary ingredients.
Locations (1)
The Ohio State University
Columbus, Ohio, United States