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Understanding the Paradoxical Rise in Blood Glucose in the Context of a Low-carbohydrate Diet
Sponsor: Brigham Young University
Summary
The purpose of this project was to elucidate the phenomenon of elevated blood glucose in the context of dietary carbohydrate restriction. Accordingly, we sought to quantify glucagon, and related hormones, between individuals that are adhering to a low-carbohydrate diet that manifests with normal vs. elevated glucose. Moreover, we sought to test the dynamic effect of macronutrients on these same outcomes. Each participant completed 3 testing periods that included the consumption of a glucose drink, protein drink, or fat (olive oil) drink in a random order and separated by at least 2 days. Each drink was matched for volume and total calories and bloodwork was taken every 30 minutes to assess the outcomes of interest.
Key Details
Gender
All
Age Range
18 Years - 65 Years
Study Type
INTERVENTIONAL
Enrollment
24
Start Date
2021-05-15
Completion Date
2022-12-17
Last Updated
2026-07-20
Healthy Volunteers
No
Interventions
Carbohydrate Drink
300 kcal of dextrose mixed in water.
Fat Drink
300 kcal of olive oil mixed in water.
Protein Drink
300 kcal of whey protein in water.
Locations (1)
Brigham Young University
Provo, Utah, United States