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RECRUITING
NCT07714525
PHASE2

Triamcinolone Nanocapsules After Endoscopic Nasal Surgery

Sponsor: Deraya University

View on ClinicalTrials.gov

Summary

This randomised, single-masked, parallel-group clinical trial will evaluate the efficacy and safety of a topical triamcinolone acetonide-loaded polymeric nanocapsule formulation for postoperative care following endoscopic nasal surgery. Participants will receive either the investigational triamcinolone acetonide-loaded nanocapsule formulation or standard normal saline nasal irrigation. Postoperative nasal healing, inflammation, patient-reported sinonasal symptoms, postoperative complications, and corticosteroid-related adverse effects will be compared between the two groups.

Official title: Clinical Evaluation of Triamcinolone Acetonide-loaded Nanoparticles For Nasal Postoperative Application

Key Details

Gender

All

Age Range

18 Years - 60 Years

Study Type

INTERVENTIONAL

Enrollment

50

Start Date

2026-05-01

Completion Date

2027-06-01

Last Updated

2026-07-20

Healthy Volunteers

No

Interventions

DRUG

Triamcinolone Acetonide-Loaded Polymeric Nanocapsules

Triamcinolone acetonide incorporated into polymeric nanocapsules prepared using a nanoprecipitation method will be administered topically to the postoperative nasal cavity.

OTHER

Normal Saline Nasal Irrigation

Participants will receive postoperative nasal irrigation with 0.9% sodium chloride solution.

Locations (1)

Deraya university, faculty of pharmacy

Minya, Menia Governorate, Egypt