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RECRUITING
NCT07715201
NA

A Pilot Study of HME Amino Acid Supplementation on Strength, Performance, and Recovery in Trained Adult Males

Sponsor: Orivian inc

View on ClinicalTrials.gov

Summary

This pilot randomized controlled trial evaluates HME (Human Muscle Equivalent), a free-form amino acid supplement formulated to match the amino acid composition of human skeletal muscle, taken at its Health Canada licensed dose (3 g powder plus one 50 mg slow-release beta-alanine capsule daily). Trained adult males (competitive athletes or certified fitness professionals) are randomized to HME or an identical-appearing placebo for 10 weeks: a 2-week supplement-only lead-in followed by 8 weeks of supplement plus supervised resistance training. The primary aim is to estimate the effect of HME on composite maximal strength (1-repetition maximum leg press plus chest press) compared with placebo. Secondary measures include isometric knee-extension strength, countermovement jump height, and subjective recovery.

Official title: A Pilot Randomized, Double-Blind, Placebo-Controlled Trial of HME (Human Muscle Equivalent) Supplementation on Strength, Body Composition, Athletic Performance, and Recovery in Trained Adults

Key Details

Gender

MALE

Age Range

18 Years - 45 Years

Study Type

INTERVENTIONAL

Enrollment

50

Start Date

2026-06-29

Completion Date

2027-03-30

Last Updated

2026-07-20

Healthy Volunteers

Yes

Interventions

DIETARY_SUPPLEMENT

HME (Human Muscle Equivalent)

HME (Human Muscle Equivalent) is a two-component amino acid formulation taken together as a single daily serving: a 3 g free-form amino acid powder matched to the human skeletal muscle amino acid profile, plus a slow-release capsule containing 50 mg beta-alanine. Both components together constitute HME. Health Canada NPN 80148183 (powder) and 80148185 (capsule).

DIETARY_SUPPLEMENT

Placebo

Maltodextrin powder and capsule matched for appearance, volume, and taste.

Locations (1)

The Institute of Human Mechanics/ JUNXION Performance

Toronto, Ontario, Canada