Clinical Research Directory

Inclusion Criteria: * For inclusion in the study, subjects must fulfil all of the following criteria: 1. Provision of informed consent. 2. Female or male aged 18 years or above. 3. Established diagnosis of PD according to MDS criteria 4. Patients with bowel symptoms post-dating and related to a diagnosis of PD. 5. PD patients suffering from constipation defined by Cleveland Clinic (Wexner) constipation score ≥10 confirmed at Baseline. 6. Only TAI treatment naïve patient (not having previously used any particular TAI system). 7. Judged eligible for TAI as per standardized treatment pathway . 8. Able to read, write and understand information given to them regarding the study. Exclusion Criteria Any of the following is regarded as a criterion for exclusion from the study: * Any confirmed or suspected diagnosis of anal or colorectal stenosis, active inflammatory bowel disease, acute diverticulitis, severe diverticulosis, colorectal cancer, ischemic colitis, history of life-threatening autonomic dysreflexia, bleeding disorders, unspecified peri-anal conditions. * Other significant neurological diseases (defined as all neurological diseases except for minor functional neurological syndromes or non-PD related neuro complications). * Opioid consumption ≤24 hours prior enrolment. * Taking probiotics in the past 30 days. * Antibiotic therapy in the past 3 weeks. * Performed endoscopic polypectomy within 4 weeks prior enrolment. * Ongoing, confirmed pregnancy or lactation. * Any neuromodulation that can affect the pelvic organ function. * Current treatment of prokinetics. * Any other condition, as judged by the investigator, might make follow-up or investigations inappropriate. Exclusion Criteria: \-