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COMPLETED
NCT07716579
NA

Assessment of Endocrine and Metabolic Late Effects After Childhood Brain Tumor Treatment

Sponsor: Institute of Oncology Ljubljana

View on ClinicalTrials.gov

Summary

This prospective, single-group interventional study evaluates endocrine and metabolic late effects in survivors of primary brain tumors treated during childhood. According to the study protocol, participants were prospectively assigned to undergo the Study-Specific Endocrine and Metabolic Late-Effects Assessment. The assessment included anthropometric measurements, repeated blood pressure measurements, clinical endocrine evaluation, fasting laboratory testing, and protocol-defined bone and vascular assessments. The purpose of the study was to identify the frequency and severity of endocrine and metabolic late effects and to evaluate their associations with tumor characteristics, previous cancer treatment, age at diagnosis, and physical functioning.

Official title: Late Endocrine and Metabolic Consequences of Treatment of Primary Brain Tumors in Childhood

Key Details

Gender

All

Age Range

5 Years - 35 Years

Study Type

INTERVENTIONAL

Enrollment

12

Start Date

2023-07-03

Completion Date

2025-12-31

Last Updated

2026-08-13

Healthy Volunteers

No

Interventions

OTHER

Study-Specific Endocrine and Metabolic Late-Effects Assessment

According to the study protocol, participants underwent a study-specific assessment to identify endocrine and metabolic late effects after treatment of a primary brain tumor during childhood. The assessment included anthropometric measurements, repeated blood pressure measurements, clinical assessment of endocrine and pubertal status, and fasting laboratory testing of endocrine and metabolic markers. Vascular assessment included measurement of carotid intima-media thickness. Bone mineral density, body composition, and pulse wave velocity assessments were performed or arranged according to the protocol when the relevant results were not already available.

Locations (1)

Institute of Oncology Ljubljana

Ljubljana, Slovenia