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Vitamin D Therapy to Prevent Recurrent Preeclampsia in High-Risk Pregnancies
Sponsor: CMH Multan Institute of Medical Sciences
Summary
The goal of this clinical trial is to determine whether vitamin D supplementation can reduce the recurrence of preeclampsia in pregnant women with a previous history of preeclampsia. The main questions the study aims to answer are: \- Does daily vitamin D supplementation reduce the recurrence of preeclampsia compared with a placebo? Researchers will randomly assign 146 eligible pregnant women to receive either vitamin D supplements or a placebo. The two groups will be compared to determine whether vitamin D lowers the risk of recurrent preeclampsia. Participants will: * Be randomly assigned to receive either 4000 IU oral vitamin D once daily or a matching placebo. * Take the assigned study medication daily until 36 weeks of gestation. * Attend follow-up visits every 2 weeks for blood pressure measurement and clinical assessment. * Have serum vitamin D levels measured every 4 weeks to monitor for vitamin D toxicity. * Undergo urine testing for protein if blood pressure is elevated to assess for preeclampsia. The results of this study will help determine whether vitamin D supplementation is an effective and safe strategy for preventing recurrent preeclampsia in women at high risk.
Official title: Preventing Preeclampsia Recurrence in High-Risk Pregnancies Using Vitamin D Therapy: A Randomized Controlled Trial
Key Details
Gender
FEMALE
Age Range
20 Years - 45 Years
Study Type
INTERVENTIONAL
Enrollment
146
Start Date
2025-08-01
Completion Date
2026-01-30
Last Updated
2026-07-21
Healthy Volunteers
No
Conditions
Interventions
Vitamin D (Cholecalciferol )
Vitamin D 4000 IU will be administered orally once daily from enrollment until 36 weeks of gestation. They will attend follow-up visits every 2 weeks for blood pressure monitoring and clinical assessment, with serum vitamin D levels measured every 4 weeks.
Placebo
A matching placebo with the same taste, color, and consistency as vitamin D will be administered orally once daily from enrollment until 36 weeks of gestation for comparison with vitamin D supplementation.
Locations (1)
CMH Multan Institute of Medical Sciences
Multan, Punjab Province, Pakistan