Clinical Research Directory
Browse clinical research sites, groups, and studies.
Early Postoperative L-arginine and Acute Kidney Injury After Cardiac Surgery
Sponsor: Xijing Hospital
Summary
Acute kidney injury (AKI) is common after cardiac surgery, yet effective protective strategies remain limited. L-arginine is the substrate for endogenous nitric oxide (NO) synthesis and may improve renal perfusion and endothelial function. investigators emulated a target trial to evaluate whether early perioperative L-arginine was associated with a lower risk of AKI after cardiac surgery.
Official title: Early Postoperative L-arginine and Acute Kidney Injury After Cardiac Surgery: a Target Trial Emulation
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
OBSERVATIONAL
Enrollment
5000
Start Date
2026-07-20
Completion Date
2026-08-20
Last Updated
2026-07-22
Healthy Volunteers
No
Conditions
Interventions
L-arginine
Initiation of L-arginine within 3 postoperative days