Clinical Research Directory

Inclusion Criteria: * Individuals with type 2 diabetes mellitus were eligible if they were aged ≥19 years * Individuals with subclinical atherosclerosis or metabolic syndrome, defined as at least one of the following: * Carotid intima-media thickness ≥ 1 mm * Ankle-brachial index \< 0.9 - Pulse wave velocity ≥ 9 m/s * Flow-mediated vasodilatation \< 5% * Coronary artery calcium score ≥ 40 * Coronary artery stenosis ≥ 20% or ≤ 70% * Peripheral artery occlusive disease ≥ 20% * Metabolic syndrome * Individuals with HbA1c ≤ 9.9% * Individuals who voluntarily agree to participate in the study and provide written informed consent Exclusion Criteria: * Patients with a history of major cardiovascular events, including myocardial infarction, stroke, or heart failure * Patients with heart failure (NYHA I\~IV) * Patients with current active bleeding or suspected bleeding * Patients with suspected bleeding tendency or hematologic disorder, such as hemophilia or thrombocytopenia * Patients recently diagnosed with gastrointestinal ulcerative disease * Patients with inadequately controlled hypertension, defined as systolic blood pressure ≥ 180 mmHg or diastolic blood pressure ≥ 110 mmHg * Patients with severe renal dysfunction, defined as estimated glomerular filtration rate \< 30 mL/min/1.73 m² * Patients with liver enzyme levels greater than 3 times the upper limit of normal or chronic liver disease * Individuals currently taking antiplatelet or antithrombotic agents * Individuals who are pregnant or breastfeeding * Patients with a history of hypersensitivity to any component of the study drugs * Patients with complications of coronary artery stenosis * Patients with QT prolongation * Patients with a sigmoid-shaped ventricular septum or risk of sigmoid-shaped ventricular septum * Individuals with alcohol addiction * Patients with asthma * Patients deemed unsuitable for participation in the study based on the investigator's judgment