Clinical Research Directory
Browse clinical research sites, groups, and studies.
Acetaminophen vs Placebo for Postoperative Analgesia After Abdominal Surgery
Sponsor: Konya City Hospital
Summary
This study investigates whether oral acetaminophen, when added to standard pain management, reduces opioid use and pain after major abdominal surgery, compared to a placebo (inactive pill). Patients undergoing planned abdominal surgery under general anesthesia will be randomly assigned to receive either acetaminophen or a placebo tablet before surgery and every 6 hours afterward for 48 hours, in addition to their usual pain medication. Researchers will measure how much opioid pain medication patients need, how much pain they report, and how satisfied they are with their pain control during the first two days after surgery. The goal is to determine whether oral acetaminophen provides a genuine benefit beyond placebo in reducing opioid use while maintaining adequate pain control.
Official title: Comparison of Placebo and Acetaminophen on Postoperative Opioid Consumption in Non-Cardiac Abdominal Surgery
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
1504
Start Date
2026-09-05
Completion Date
2027-08-01
Last Updated
2026-08-25
Healthy Volunteers
No
Conditions
Interventions
Acetaminophen
Intervention 1: Acetaminophen (Type: Drug) Oral acetaminophen 1000 mg tablet, administered 30 minutes before surgery and every 6 hours postoperatively until 48 hours after surgery. Other Name(s): Paracetamol Intervention 2: Placebo (Type: Other / Drug) Oral placebo tablet, visually identical to the acetaminophen tablet, administered on the same schedule (30 minutes before surgery and every 6 hours postoperatively until 48 hours after surgery).