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Objective Neurocognitive Assessment of Young Children With Sickle Cell Disease by Eye-Tracking
Sponsor: Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Summary
Evidence indicates that Sickle Cell Disease (SCD) threatens neurodevelopmental outcome. Although children with SCD may be heterogeneously affected, neurocognitive impairment may already be present in toddlers. Neurocognitive functioning is an important determinant of adaptive daily life functioning later in life and is influenced by both the course of the disease and the often suboptimal environment in which afflicted children grow up. Early identification of children at the highest risk of neurocognitive impairment would enable the deployment of early interventions to mitigate the detrimental effects of SCD on the developing brain. In order to develop such interventions, a deeper understanding of the underlying pathophysiological mechanisms is required. Therefore the main aim is to study early neurocognitive functioning and development in children with SCD between the ages of 6 and 24 months old.
Key Details
Gender
All
Age Range
6 Months - 24 Months
Study Type
OBSERVATIONAL
Enrollment
93
Start Date
2023-03-16
Completion Date
2025-12-02
Last Updated
2026-07-22
Healthy Volunteers
Yes
Interventions
eyetracking
Eye-tracking is an objective, non-invasive method and particularly suited to assess neurodevelopmental outcome in infants.
blood work
proteomics analyses methylation analyses
Strengths and difficulties questionnaire (SDQ)
The strengths and difficulties questionnaire is a conventional instrument used to measure the presence of psychosocial problems, the child's strengths and the influence of psychosocial problems on daily functioning.
TNO AZL Preschool Children Quality of Life (TAPQOL)
The TNO-AZL Preschool Children Quality of Life is a questionnaire that measures the health-related quality of life of children over the last three months
Bayley Scale of Infant Development III (BSID)
The Bayley Scale of Infant Development is a conventional instrument used to measure developmental outcome in infants
Locations (1)
Amsterdam UMC
Amsterdam, Netherlands