Clinical Research Directory

Inclusion Criteria: 1. U.S. Military Veterans 2. DSM-5 PTSD diagnosis verified by the Clinician-Administered PTSD Scale for DSM-5 (CAPS-5) 3. Cannabis use at least once per week over the past 3 months 4. If on psychotropic medication or in psychotherapy (excluding trauma-focused PTSD therapy; see exclusion criteria), regimen must be stable for =1 month 5. English-speaking and reading 6. Willing and able to use a smartphone and wearable device for 2 weeks Exclusion Criteria: 1. Severe substance use disorder (excluding cannabis), as acute withdrawal or other drug effects could confound data; mild/moderate non-cannabis disorders permitted with monitoring 2. Lifetime diagnosis of schizophrenia or other primary psychotic disorder due to potential confounding of EMA responses 3. Severe depression or high suicide risk; such Veterans will be referred for treatment and may be re-evaluated once stabilized 4. Cognitive or neurodegenerative disorder impairing ability to use EMA tools (e.g., moderate/severe TBI or dementia) 5. Veterans currently engaged in evidence-based trauma-focused therapy (e.g., CPT, PE, EMDR), will be excluded to isolate naturalistic symptom variability, as therapy can substantially impact PTSD symptoms; these individuals will be invited to re-contact the study post-treatment for consideration 6. Lack of smartphone ownership