Clinical Research Directory

Salivary Angiotensin-Converting Enzyme and Periodontal Disease in Cardiovascular Disease

Sponsor: Suleyman Demirel University

Summary

The goal of this observational study is to learn whether the renin-angiotensin system, measured by angiotensin-converting enzyme (ACE) and angiotensin-converting enzyme 2 (ACE2) in saliva and blood, is associated with periodontal disease severity in adults undergoing cardiovascular evaluation. The main questions it aims to answer are: * Are salivary and blood ACE and ACE2 levels different according to periodontal disease severity? * Do salivary ACE and ACE2 levels reflect the corresponding blood levels? * Are ACE and ACE2 levels related to clinical measures of periodontal disease? Participants will: * Complete medical and dental history assessments. * Undergo a comprehensive periodontal examination, including measurements of plaque, gingival inflammation, bleeding on probing, probing pocket depth, clinical attachment loss, and the number of remaining teeth. * Provide saliva and blood samples for laboratory measurement of ACE and ACE2.

Official title: Salivary Angiotensin-converting Enzyme is Associated With Periodontal Disease Severity in Patients With Cardiovascular Disease

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