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Glycolytic Phenotype (vLapeak) and Magnitude of Skeletal Muscle Hypertrophy After Resistance Training
Sponsor: Technical University of Munich
Summary
The HyperLa study investigates whether a person's "glycolyticness"-the efficiency with which their body uses glycolysis for energy-can predict how much their muscles will grow (hypertrophy) in response to resistance training. Participants will undergo a specialized "vLapeak" test, which measures the maximal rate of lactate accumulation during a 10-second all-out cycling sprint, to determine their individual glycolytic power. Following this initial assessment, participants will complete eight weeks of standardized, twice-weekly resistance training focused on the lower body. The study aims to determine if individuals with higher initial vLapeak values experience greater increases in muscle size compared to those with lower values. This research may help explain why people respond differently to exercise and support the development of personalized training programs.
Official title: HyperLa: Glycolytic Phenotype (vLapeak) and Magnitude of Skeletal Muscle Hypertrophy After Resistance Training: A Multi-centre Study by the HyperLa Study Group
Key Details
Gender
All
Age Range
18 Years - 39 Years
Study Type
INTERVENTIONAL
Enrollment
120
Start Date
2026-05-04
Completion Date
2026-12-01
Last Updated
2026-07-23
Healthy Volunteers
Yes
Interventions
Hypertrophy-focused Resistance Training
Standardized training consisting of twice-weekly supervised sessions for 8 weeks. Each session includes 4 sets of 8-12 repetitions of leg press (or Smith-machine squat) and leg extensions. Training intensity progresses from an RPE of 6 to voluntary muscular failure starting from week three.
Locations (8)
University of Jyväskylä, Faculty of Sport and Health Sciences
Jyväskylä, Central Finland, Finland
Technical University of Munich, TUM School of Medicine and Health
München, Bavaria, Germany
DLR Cologne, Department of Metabolism and Human Performance
Cologne, North Rhine-Westphalia, Germany
iST University of Applied Sciences
Düsseldorf, North Rhine-Westphalia, Germany
TU Chemnitz, Sports Medicine and Exercise Therapy
Chemnitz, Saxony, Germany
Institute for Applied Training Science (IAT) Leipzig
Leipzig, Saxony, Germany
University of Limerick, Department of Physical Education and Sport Sciences (PESS)
Limerick, Limerick, Ireland
Universidad Politécnica de Madrid, Facultad de Ciencias de la Actividad Física y del Deporte (INEF)
Madrid, Madrid, Spain