Clinical Research Directory

Inclusion Criteria: Adult patients with septic shock: * Proven or suspected infection. * Persistent arterial hypotension requiring norepinephrine administration to maintain a mean arterial pressure above 65 mmHg despite adequate fluid resuscitation. * Hyperlactatemia \> 2 mmol/L. Adult critically ill control patients with sepsis without circulatory failure: * Proven or suspected infection. * Absence of persistent arterial hypotension requiring norepinephrine administration to maintain a mean arterial pressure above 65 mmHg. * An increase of at least 2 points in the SOFA score attributable to infection. Adult critically ill control patients with cardiogenic shock: * Acute cardiac disease, such as myocardial infarction. * Persistent arterial hypotension requiring norepinephrine administration to maintain a mean arterial pressure above 65 mmHg despite adequate fluid resuscitation. * Low cardiac output: cardiac index \< 2.2 L/min/m² or the need for inotropic support (including norepinephrine) to maintain a cardiac index \> 2.2 L/min/m². * Elevated left ventricular filling pressures, measured invasively or estimated by echocardiography. * Hyperlactatemia \> 2 mmol/L. Adult healthy volunteers: * Absence of active or chronic disease. * Absence of long-term medication use. * No surgery or medication intake within the previous month. * Absence of ongoing pregnancy. * Non-smoker. Exclusion Criteria: * Patients deprived of liberty by judicial or administrative decision. * Patients admitted to the intensive care unit for more than 48 hours. * Patients previously enrolled in an interventional study with overlapping follow-up. * Patients benefiting from State Medical Aid (AME).