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Clinical Practice of Hydromorphone in Multimodal Analgesia for Enhanced Recovery After Surgery (ERAS) in Knee Arthroplasty
Sponsor: China-Japan Friendship Hospital
Summary
This study proposes a multimodal analgesia regimen comprising preoperative non-steroidal anti-inflammatory drugs (NSAIDs) for preemptive analgesia, intra-articular injection at the end of surgery, and postoperative adductor canal block. The objective is to observe the analgesic efficacy and duration of hydromorphone combined with ropivacaine in the adductor canal block on resting and movement-related pain in patients following total knee arthroplasty, as well as the time to recovery from motor blockade and the incidence of drug-related adverse events.
Official title: Hydromorphone as an Adjuvant to Ropivacaine for Adductor Canal Block in Total Knee Arthroplasty: A Prospective, Randomized, Double-Blind, Controlled Trial
Key Details
Gender
All
Age Range
60 Years - 75 Years
Study Type
INTERVENTIONAL
Enrollment
90
Start Date
2026-03-10
Completion Date
2026-06-13
Last Updated
2026-07-23
Healthy Volunteers
No
Conditions
Interventions
Ropivacaine + Hydromorphone
Ultrasound-guided single-shot ACB with a 20 mL mixture of 0.5% ropivacaine and 0.5 mg hydromorphone
Ropivacaine
Ultrasound-guided single-shot adductor canal block (ACB) with 20 mL of 0.5% ropivacaine
Locations (1)
China-Japan Friendship Hospital
Beijing, Beijing Municipality, China