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Postoperative Pain After OCT or EDTA Irrigation in Regenerative Endodontic Treatment
Sponsor: TC Erciyes University
Summary
This randomized clinical trial evaluated the effect of two different irrigation solutions on postoperative pain following regenerative endodontic treatment of necrotic immature permanent teeth with apical periodontitis. Participants were randomly allocated to receive either 0.1% octenidine dihydrochloride (OCT) or 17% ethylenediaminetetraacetic acid (EDTA) during regenerative endodontic treatment. A total of 40 patients aged 9 to 16 years were included and allocated to the two intervention groups in a 1:1 ratio. Postoperative pain was recorded using a 0-100 numerical rating scale at 6, 12, and 24 hours and daily from the second through the seventh postoperative day. Analgesic use and the occurrence of flare-up were also evaluated.
Official title: Effect of Different Irrigation Protocols on Postoperative Pain Following Regenerative Endodontic Treatment: A Randomized Clinical Trial
Key Details
Gender
All
Age Range
8 Years - 16 Years
Study Type
INTERVENTIONAL
Enrollment
40
Start Date
2025-10-01
Completion Date
2026-05-08
Last Updated
2026-07-23
Healthy Volunteers
Yes
Conditions
Interventions
Regenerative Endodontic Treatment Using Different Irrigation Solutions
Regenerative endodontic treatment was performed using either 0.1% octenidine dihydrochloride (OCT) or 17% ethylenediaminetetraacetic acid (EDTA) as the allocated irrigation solution. In both groups, 20 mL of the assigned irrigant was applied for 5 minutes during each treatment visit and ultrasonically activated for 1 minute.
Locations (1)
Erciyes Üniversitesi Diş Hekimliği Fakültesi
Kayseri, Kayseri, Turkey (Türkiye)