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Low-FODMAP vs Lactose-Gluten-Free Diet in Patients With Irritable Bowel Syndrome
Sponsor: Antalya Bilim University
Summary
Irritable bowel syndrome (IBS) is a common functional gastrointestinal disorder that substantially affects quality of life. Dietary therapy is considered one of the primary treatment approaches; however, the optimal sequence of dietary interventions remains unclear. This randomized crossover trial was designed to compare the effects of a low-FODMAP diet and a lactose-free, gluten-free diet on gastrointestinal symptoms, psychological status, anthropometric measurements, and biochemical parameters in adults with IBS. Participants were randomly assigned to one of two dietary sequences, with each intervention lasting four weeks and separated by a one-week washout period. Outcomes were assessed using validated symptom and psychological questionnaires together with anthropometric and biochemical measurements before and after each intervention period.
Official title: Comparative Effects of Low-FODMAP and Lactose-Gluten-Free Diets on Gastrointestinal Symptoms and Mental Health in Irritable Bowel Syndrome: A Randomized Crossover Trial
Key Details
Gender
All
Age Range
18 Years - 64 Years
Study Type
INTERVENTIONAL
Enrollment
72
Start Date
2020-09-01
Completion Date
2022-01-20
Last Updated
2026-07-23
Healthy Volunteers
No
Conditions
Interventions
Low-FODMAP Diet
Participants followed a low-FODMAP diet for 4 weeks under the supervision of a dietitian.
Lactose- and Gluten-Free Diet
Participants followed a lactose- and gluten-free diet for 4 weeks under the supervision of a dietitian.
Locations (1)
Istanbul University-Cerrahpaşa, Cerrahpaşa Faculty of Medicine, Department of Gastroenterology
Istanbul, Turkey (Türkiye)