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Tamsulosin Monotherapy Versus Combination Therapy With Tadalafil (2.5 mg vs 5 mg) in Managing Male LUTS Secondary to BPH
Sponsor: Ain Shams University
Summary
This study aims to evaluate the short-term impact and clinical outcomes of tamsulosin monotherapy versus combination therapy with tamsulosin plus tadalafil (2.5 mg vs. 5 mg) on lower urinary tract symptoms (LUTS) severity and patient quality of life in men with benign prostatic hyperplasia (BPH). It also seeks to determine whether the lower tadalafil dose provides adequate symptom relief while minimizing adverse effects over a 12-week follow-up period.
Official title: Safety and Efficacy of Tamsulosin Monotherapy Versus Combination Therapy With Tadalafil (2.5 mg vs 5 mg) in Managing Male LUTS Secondary to BPH
Key Details
Gender
All
Age Range
45 Years - Any
Study Type
INTERVENTIONAL
Enrollment
90
Start Date
2026-07-01
Completion Date
2027-01-01
Last Updated
2026-07-23
Healthy Volunteers
No
Conditions
Interventions
Tamsulosin 0.4 mg + Tadalafil 2.5 mg
Patients will receive Tamsulosin 0.4 mg once daily + Tadalafil 2.5 mg once daily
Tamsulosin 0.4 mg + Tadalafil 5 mg
Patients will receive Tamsulosin 0.4 mg once daily + Tadalafil 5 mg once daily
Tamsulosin 0.4 mg
Patients will receive Tamsulosin 0.4 mg once daily (monotherapy)
Locations (1)
Ain Shams University
Cairo, Cairo Governorate, Egypt