Clinical Research Directory

Inclusion Criteria: * Adults aged 18 years or older. * Histologically confirmed diagnosis of a malignant neoplasm of the head and neck region. * Receipt of radiotherapy, chemotherapy, or concurrent chemoradiotherapy for head and neck cancer. * Clinically documented oral mucositis of World Health Organization grade 1 or higher. * Previous treatment of oral mucositis with either laser therapy or ozone therapy as part of routine clinical care. * Availability of baseline oral mucositis severity assessment and at least one post-treatment assessment. * Availability of sufficient clinical records to determine eligibility and evaluate the study outcomes. Exclusion Criteria: * Active oral infection at the time of oral mucositis assessment, including oral candidiasis or herpes simplex infection. * Use of another specific treatment for oral mucositis within the 2 weeks before initiation of laser therapy or ozone therapy, when documented. * Medical conditions contraindicating laser therapy or ozone therapy, including photosensitivity disorders or severe respiratory disease. * Concurrent participation in another interventional clinical study that could have affected oral mucositis outcomes. * Pregnancy or breastfeeding at the time of treatment, when documented. * Neurological, psychiatric, or cognitive conditions that could have impaired reliable pain assessment or questionnaire completion. * Previous treatment with both laser therapy and ozone therapy during the same episode of oral mucositis. * Incomplete or insufficient clinical records for assessment of the primary outcome.