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Adjunctive Subgingival Pomegranate Peel Extract Gel for Stage II-III Periodontitis
Sponsor: gehad samy
Summary
This randomized, triple-blind, placebo-controlled split-mouth clinical trial aims to evaluate the clinical and biochemical efficacy of subgingival pomegranate peel extract gel as an adjunct to scaling and root planing (SRP) in the treatment of Stage II-III periodontitis. Thirty-two participants diagnosed with Stage II-III periodontitis will receive SRP in all selected periodontal sites. Test sites will receive locally delivered pomegranate peel extract gel, while contralateral control sites will receive a placebo gel. Clinical periodontal parameters, including probing pocket depth (PPD), clinical attachment level (CAL), plaque index (PI), gingival index (GI), bleeding on probing (BOP), and gingival crevicular fluid levels of matrix metalloproteinase-8 (MMP-8), will be assessed at baseline, 1 month, 3 months, and 6 months to evaluate whether adjunctive pomegranate peel extract gel improves periodontal healing compared with SRP alone.
Official title: Adjunctive Subgingival Pomegranate Peel Extract Gel for Stage II-III Periodontitis: A Randomized Split-Mouth Trial
Key Details
Gender
All
Age Range
30 Years - 60 Years
Study Type
INTERVENTIONAL
Enrollment
32
Start Date
2026-07-01
Completion Date
2027-01
Last Updated
2026-07-24
Healthy Volunteers
No
Conditions
Interventions
Pomegranate Peel Extract Gel
Locally delivered subgingival gel containing pomegranate peel extract administered after scaling and root planing.
Placebo gel
Placebo gel without active ingredient, identical in appearance and consistency to the experimental gel, administered after scaling and root planing.
Locations (1)
Faculty of Dental Medicine for Girls, Al-Azhar University
Cairo, Cairo Governorate, Egypt