Clinical Research Directory

Inclusion Criteria: * Healthy adults aged 18 to 65 years * Non-smokers (no smoking or vaping within the past 6 months) * No chronic lung disease or significant chronic medical conditions * No current or recent (within 1 month) upper or lower respiratory infection * Able and willing to provide informed consent * Have not received the current seasonal influenza vaccine * Able to comply with study procedures and follow-up visits Exclusion Criteria: * Age under 18 or over 65 years * Pregnancy or breastfeeding * Prisoners * Non-English speaking individuals * Immunocompromised individuals (including HIV/AIDS, immunosuppressive therapy, chemotherapy, or primary immunodeficiency) * Chronic medical conditions including asthma, chronic lung, liver, kidney, neurologic, hematologic, metabolic, or significant cardiovascular disease (except isolated hypertension) * History of chronic sinusitis or significant nasal allergies requiring frequent or daily treatment * Acute moderate or severe illness at time of enrollment, with or without fever * Receipt of influenza vaccine during the current season or within the past 2 weeks * Receipt of another live vaccine within 4 weeks prior to enrollment or planned during study period * Use of influenza antiviral medications (e.g., oseltamivir, zanamivir) within 48 hours prior to vaccination or planned use within 14 days after vaccination * History of severe allergic reaction to influenza vaccine or any component of FluMist (including egg allergy if applicable) * History of Guillain-Barré syndrome following influenza vaccination * Any condition that, in the opinion of the investigator, would interfere with study participation or interpretation of results