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Rapid or Ultra-rapid Diagnosis of Myocardial Infarction Using High-Sensitivity Cardiac Troponin on Hospital Presentation
Sponsor: Herlev and Gentofte Hospital
Summary
People with chest pain are often tested for a heart attack using a blood test called high-sensitivity cardiac troponin (hs-cTn). Traditionally, this blood test is repeated 3 hours after the first sample. Newer guidelines recommend repeating the test after 1 hour instead, which may allow patients to receive a diagnosis and leave the hospital sooner. The purpose of the DanRUSH trial is to compare these two strategies: repeating the blood test after 1 hour versus after 3 hours in adults with suspected acute coronary syndrome. The study will evaluate whether the 1-hour strategy is as safe as the 3-hour strategy while reducing the length of hospital stay. DanRUSH is a nationwide, pragmatic, cluster-randomized trial conducted in emergency- and cardiology departments across Denmark. The results will help determine the best timing for blood testing in patients with suspected heart attack and improve future care for these patients.
Official title: Danish Randomized Trial of Rapid or Ultra-rapid Diagnosis of Myocardial Infarction Using High-Sensitivity Cardiac Troponin on Hospital Presentation
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
28000
Start Date
2026-09-01
Completion Date
2029-02-01
Last Updated
2026-08-06
Healthy Volunteers
No
Conditions
Interventions
0/3-hour high-sensitivity cardiac troponin algorithm
High-sensitivity cardiac troponin measurements obtained at presentation and 3 hours after the initial sample as part of the conventional diagnostic strategy for suspected acute coronary syndrome.
0/1-hour high-sensitivity cardiac troponin algorithm
High-sensitivity cardiac troponin measurements obtained at presentation and 1 hour after the initial sample as part of the accelerated diagnostic strategy for suspected acute coronary syndrome.
Locations (11)
Aalborg University Hospital
Aalborg, Denmark
Bispebjerg & Frederiksberg Hospital
Bispebjerg, Denmark
Esbjerg og Grindsted Sygehus
Esbjerg, Denmark
Gødstrup Regional Hospital
Gødstrup, Denmark
Herlev & Gentofte Hospital
Herlev, Denmark
Nordsjællands Hospital
Hillerød, Denmark
Amager & Hvidovre Hospital
Hvidovre, Denmark
Nykøbing Falster County Hospital
Nykøbing Falster, Denmark
Odense University Hospital
Odense, Denmark
Svendborg Hospital
Svendborg, Denmark
Central Jutland Regional Hospital (Viborg Hospital & Silkeborg Hospital)
Viborg, Denmark