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NCT07727135
NA

Rapid or Ultra-rapid Diagnosis of Myocardial Infarction Using High-Sensitivity Cardiac Troponin on Hospital Presentation

Sponsor: Herlev and Gentofte Hospital

View on ClinicalTrials.gov

Summary

People with chest pain are often tested for a heart attack using a blood test called high-sensitivity cardiac troponin (hs-cTn). Traditionally, this blood test is repeated 3 hours after the first sample. Newer guidelines recommend repeating the test after 1 hour instead, which may allow patients to receive a diagnosis and leave the hospital sooner. The purpose of the DanRUSH trial is to compare these two strategies: repeating the blood test after 1 hour versus after 3 hours in adults with suspected acute coronary syndrome. The study will evaluate whether the 1-hour strategy is as safe as the 3-hour strategy while reducing the length of hospital stay. DanRUSH is a nationwide, pragmatic, cluster-randomized trial conducted in emergency- and cardiology departments across Denmark. The results will help determine the best timing for blood testing in patients with suspected heart attack and improve future care for these patients.

Official title: Danish Randomized Trial of Rapid or Ultra-rapid Diagnosis of Myocardial Infarction Using High-Sensitivity Cardiac Troponin on Hospital Presentation

Key Details

Gender

All

Age Range

18 Years - Any

Study Type

INTERVENTIONAL

Enrollment

28000

Start Date

2026-09-01

Completion Date

2029-02-01

Last Updated

2026-08-06

Healthy Volunteers

No

Interventions

DIAGNOSTIC_TEST

0/3-hour high-sensitivity cardiac troponin algorithm

High-sensitivity cardiac troponin measurements obtained at presentation and 3 hours after the initial sample as part of the conventional diagnostic strategy for suspected acute coronary syndrome.

DIAGNOSTIC_TEST

0/1-hour high-sensitivity cardiac troponin algorithm

High-sensitivity cardiac troponin measurements obtained at presentation and 1 hour after the initial sample as part of the accelerated diagnostic strategy for suspected acute coronary syndrome.

Locations (11)

Aalborg University Hospital

Aalborg, Denmark

Bispebjerg & Frederiksberg Hospital

Bispebjerg, Denmark

Esbjerg og Grindsted Sygehus

Esbjerg, Denmark

Gødstrup Regional Hospital

Gødstrup, Denmark

Herlev & Gentofte Hospital

Herlev, Denmark

Nordsjællands Hospital

Hillerød, Denmark

Amager & Hvidovre Hospital

Hvidovre, Denmark

Nykøbing Falster County Hospital

Nykøbing Falster, Denmark

Odense University Hospital

Odense, Denmark

Svendborg Hospital

Svendborg, Denmark

Central Jutland Regional Hospital (Viborg Hospital & Silkeborg Hospital)

Viborg, Denmark