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Temporal Interference Stimulation of Hypothalamus in Patients With Narcolepsy Type 1
Sponsor: Xijing Hospital
Summary
Narcolepsy type 1 (NT1) is a chronic brain disorder caused by selective loss or dysfunction of orexin (hypocretin) neurons in the lateral hypothalamus, for which current pharmacological treatments offer limited efficacy. Temporal interference (TI) stimulation is a recently developed noninvasive neuromodulation technique that enables focal modulation of deep brain structures. In this randomized, double-blind study, we developed a theta-burst patterned TI protocol and evaluated its effects in patients with NT1.
Official title: Efficacy and Safety of Temporal Interference Stimulation of Hypothalamus in Patients With Narcolepsy Type 1: A Randomised, Double-blind, Sham-Controlled, Single-Centre Trial
Key Details
Gender
All
Age Range
12 Years - 60 Years
Study Type
INTERVENTIONAL
Enrollment
24
Start Date
2026-08-01
Completion Date
2027-12
Last Updated
2026-08-05
Healthy Volunteers
No
Conditions
Interventions
Active Temporal Interference Stimulation
For the active TI stimulation, the current was applied for 40 minutes per session.
Sham Temporal Interference Stimulation
For the sham stimulation, a brief 30-second current was delivered at the beginning and at the end of each session, with no current applied in between.
Locations (1)
Xijing Hospital
Xi'an, Shaanxi, China