Clinical Research Directory
Browse clinical research sites, groups, and studies.
Summary
Screen2Prevent is a study intended to improve HIV prevention and detection through implementation and evaluation of three different broad-scale HIV screening approaches a) targeted, b) universally offered opt-in, and c) universally offered opt-out in Emergency Departments (EDs) by leveraging digital health to identify and link adolescents seeking care in the ED to HIV Pre-Exposure Prophylaxis (PrEP)/Antiretroviral treatment (ART).
Official title: Screen2Prevent (S2P): Using Digital Health to Improve HIV Screening and Prevention for Adolescents in the Emergency Department
Key Details
Gender
All
Age Range
14 Years - 24 Years
Study Type
INTERVENTIONAL
Enrollment
84000
Start Date
2026-06-16
Completion Date
2028-10-31
Last Updated
2026-08-17
Healthy Volunteers
Yes
Conditions
Interventions
HIV screening strategies
The intervention includes three screening strategies (targeted, universally offered opt-in, and universally offered opt-out) which will each be employed, one at a time, for a period of 8 months. A targeted screening approach is defined as screening those who are at increased likelihood for acquiring HIV. Alternatively, a universally offered screening approach is defined as screening all, regardless of behavior informing risk. There are two types of universally offered screening, opt-in and opt-out. With opt-in screening, all patients are offered screening, which they may then agree to undergo. Opt-out screening consists of notifying patients that the test will be conducted unless they explicitly decline. Each screening strategy implements the cSHS, a text messaging platform, and Clinical Decision Support for identification of youth needing HIV treatment/prevention and linkage to services.
Locations (5)
University of South Florida
Tampa, Florida, United States
Emory Atlanta Adolescent Consortium
Atlanta, Georgia, United States
Johns Hopkins University
Baltimore, Maryland, United States
St. Jude Children's Research Hospital
Memphis, Tennessee, United States
Baylor College of Medicine
Houston, Texas, United States