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RECRUITING
NCT07728123
NA

Screen2Prevent (S2P)

Sponsor: Westat

View on ClinicalTrials.gov

Summary

Screen2Prevent is a study intended to improve HIV prevention and detection through implementation and evaluation of three different broad-scale HIV screening approaches a) targeted, b) universally offered opt-in, and c) universally offered opt-out in Emergency Departments (EDs) by leveraging digital health to identify and link adolescents seeking care in the ED to HIV Pre-Exposure Prophylaxis (PrEP)/Antiretroviral treatment (ART).

Official title: Screen2Prevent (S2P): Using Digital Health to Improve HIV Screening and Prevention for Adolescents in the Emergency Department

Key Details

Gender

All

Age Range

14 Years - 24 Years

Study Type

INTERVENTIONAL

Enrollment

84000

Start Date

2026-06-16

Completion Date

2028-10-31

Last Updated

2026-08-17

Healthy Volunteers

Yes

Conditions

Interventions

OTHER

HIV screening strategies

The intervention includes three screening strategies (targeted, universally offered opt-in, and universally offered opt-out) which will each be employed, one at a time, for a period of 8 months. A targeted screening approach is defined as screening those who are at increased likelihood for acquiring HIV. Alternatively, a universally offered screening approach is defined as screening all, regardless of behavior informing risk. There are two types of universally offered screening, opt-in and opt-out. With opt-in screening, all patients are offered screening, which they may then agree to undergo. Opt-out screening consists of notifying patients that the test will be conducted unless they explicitly decline. Each screening strategy implements the cSHS, a text messaging platform, and Clinical Decision Support for identification of youth needing HIV treatment/prevention and linkage to services.

Locations (5)

University of South Florida

Tampa, Florida, United States

Emory Atlanta Adolescent Consortium

Atlanta, Georgia, United States

Johns Hopkins University

Baltimore, Maryland, United States

St. Jude Children's Research Hospital

Memphis, Tennessee, United States

Baylor College of Medicine

Houston, Texas, United States