Clinical Research Directory

Inclusion Criteria: 1. Patients ≥ 18 years diagnosed with spontaneous intracranial hemorrhage (ICH) by CT scan and treated maximally within the first 24 hours. 2. Prior functional independence defined as modified Rankin scale (mRS) ≤ 3. 3. Time from symptom onset or last known seen well ≤ 24 hours. 4. Signed informed consent by the patient or their representative. Exclusion Criteria: 1. Age \< 18 years 2. Intracranial hemorrhage secondary to trauma, ischemic stroke, or fibrinolytic or endovascular treatment. 3. Spontaneous ICH with limitation of therapeutic effort (LTE) within the first 24 hours. LTE is defined as the withholding or withdrawal of potentially life-sustaining treatment and/or the initiation of comfort care measures with the expectation that the patient may die as a result. Potentially life-sustaining treatments include: orotracheal intubation and mechanical ventilation, cardiopulmonary resuscitation, and neurosurgical treatments (intracranial pressure monitoring, external ventricular drainage, hematoma evacuation, decompressive craniectomy). LTE is not considered to apply if only a do-not-resuscitate (DNR) order was established, without limitation of any other treatment. 4. Prior functional dependence, defined as mRS \> 3 5. Time from symptom onset or last known seen well \>24 hours