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ACTIVE NOT RECRUITING
NCT07730255
NA

Exercise and Taurine Supplementation on Intramuscular Fat in Older Women With Obesity

Sponsor: University of Sao Paulo

View on ClinicalTrials.gov

Summary

This randomized clinical trial aims to investigate the effects of multicomponent concurrent exercise training associated or not with taurine supplementation on intramuscular fat infiltration, physical performance, transcriptomic profile, and metabolomic profile in older women with obesity. Forty women aged 60 to 75 years with obesity will be randomized into four groups: control, exercise, taurine, and exercise plus taurine. The intervention will last 16 weeks. Outcomes include magnetic resonance imaging, body composition, muscle biopsy, blood biomarkers, functional capacity tests, transcriptomic analysis, and metabolomic analysis.

Official title: The Impact of Physical Exercise Associated or Not With Taurine Supplementation on Intramuscular Fat Infiltration in Older Women With Obesity: A Transcriptomic and Metabolomic Approach

Key Details

Gender

FEMALE

Age Range

60 Years - 75 Years

Study Type

INTERVENTIONAL

Enrollment

44

Start Date

2026-05-01

Completion Date

2026-12

Last Updated

2026-07-28

Healthy Volunteers

No

Interventions

BEHAVIORAL

Concurrent Exercise Training

Participants will perform supervised concurrent exercise training three times per week for 16 weeks. Exercise sessions will include warm-up, resistance exercises, aerobic training, and stretching exercises, according to American College of Sports Medicine (ACSM) recommendations for older adults.

DIETARY_SUPPLEMENT

Taurine

Participants will receive 3 grams per day taurine supplementation administered orally in capsules for 16 weeks.

OTHER

Placebo

Participants will receive placebo capsules identical in appearance to taurine capsules.

Locations (1)

Escola de Educação Física e Esporte de Ribeirão Preto, Ribeirão Preto, São Paulo.

Ribeirão Preto, São Paulo, Brazil