Clinical Research Directory
Browse clinical research sites, groups, and studies.
Pipelle Versus Manual Vacuum Aspiration Cannula for Endometrial Biopsy in Women With Abnormal Uterine Bleeding
Sponsor: University of Health Sciences Lahore
Summary
women globally, often requiring endometrial tissue sampling for accurate evaluation and diagnosis. Traditional office-based sampling techniques like Pipelle are widely used, but the disposable instruments can be relatively expensive in resource-limited settings. Manual Vacuum Aspiration (MVA) using a flexible cannula is an inexpensive, reusable alternative, but clinical data comparing its performance directly to Pipelle remains limited. The objective of this randomized clinical trial is to compare Pipelle endometrial biopsy and Manual Vacuum Aspiration (MVA) cannula in terms of sample adequacy, patient satisfaction, and post-procedure complications in women presenting with abnormal uterine bleeding. Participants will be randomly assigned to undergo endometrial sampling using either a 4 mm MVA cannula or a Pipelle device without anesthesia or cervical dilation. Samples will be analyzed for histopathological diagnosis, and outcomes such as procedure pain, adequacy of tissue, and complications will be recorded.
Official title: A Comparative Study of Pipelle Versus Manual Vacuum Aspiration Cannula for Endometrial Biopsy
Key Details
Gender
FEMALE
Age Range
35 Years - Any
Study Type
INTERVENTIONAL
Enrollment
80
Start Date
2026-08-11
Completion Date
2027-08-12
Last Updated
2026-07-28
Healthy Volunteers
No
Conditions
Interventions
Manual Vacuum Aspiration (MVA) Cannula
Endometrial sampling using a 4 mm flexible polyethylene MVA cannula connected to a manual vacuum aspiration syringe without dilation or anesthesia.
Pipelle Endometrial Suction Curette
Endometrial biopsy using a flexible Pipelle device operated by pulling the internal piston to create negative pressure without dilation or anesthesia.