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Finasteride and Cutibacterium
Sponsor: University of Washington
Summary
High levels of Testosterone causes high amounts of skin bacteria (Cutibacterium Acnes) which can go into the skin during a shoulder replacement surgery and cause a terrible infection. The goal of this experiment is to have participants take Finasteride, a medication that blocks testosterone production, for 2 weeks and evaluate the following: * Blood levels of testosterone * Amount of bacteria on the skin. Participants will: * Be assigned to take Finasteride, or a placebo (a look-alike pill with no active medicine) once daily, for 2 weeks * Have a small sample of their blood collected and their skin swabbed with a Q-tip to determine Testosterone levels and bacteria on the skin * Blood draw and skin testing will take place before starting Finasteride or the placebo (day 0) and at the end of the experiment (day 14).
Key Details
Gender
MALE
Age Range
18 Years - 65 Years
Study Type
INTERVENTIONAL
Enrollment
40
Start Date
2026-08-31
Completion Date
2027-08-31
Last Updated
2026-07-28
Healthy Volunteers
Yes
Interventions
Finasteride 1 mg
Patients randomized to the experimental group will receive oral Finasteride 1 mg, taken daily, for two weeks
Placebo Control
Patients randomized to the placebo group will receive one pill containing no active medicine, taken daily, for two weeks.