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Impact of Prophylactic Bone Radiation Therapy in Patients With Bone Metastases.
Sponsor: Centre Henri Becquerel
Summary
Radiation therapy is a common treatment for painful bone metastases, proving effective in 1 to 2/3 of cases after 1 to 10 sessions, with stereotactic body radiation therapy (SBRT) likely offering superior results. Radiation therapy is also used to prevent bone events, although its use is not standardized; the decision to administer it is made by clinicians or through multidisciplinary team (MDT) discussions. Recently, it has been shown that preventive radiation therapy can reduce the risk of skeletal-related events (SREs) in patients at high risk for bone events. The objective is to compare active surveillance with preventive radiation therapy in patients at intermediate risk for bone events.
Official title: Impact of Prophylactic Bone Radiation Therapy on Morbidity and Mortality in Patients With Asymptomatic Bone Metastases and an Intermediate Risk of Bone Events.
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
154
Start Date
2026-09-01
Completion Date
2030-11-01
Last Updated
2026-07-29
Healthy Volunteers
No
Conditions
Interventions
prophylactic radiation
Patients will undergo propthylactic radiation on bone metastases
standard of care
Patients will have systemic treatment on the standard of care
Locations (2)
Institut de Cancérologie de Lorraine
Nancy, France
Centre Henri Becquerel
Rouen, France