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Perioperative Haemostasis, Procedure-Related Pain After Physiological or Pharmacological Modifications of Local Anaesthesia Around the Eyes
Sponsor: Prince of Wales Hospital, Shatin, Hong Kong
Summary
The goal of this clinical trial is to determine whether buffering, warming, or addition of hyaluronidase or tranexamic acid to lignocaine during eyelid injection of local anaesthesia reduce injection pain and procedure-related pain and improve perioperative haemostasis.
Official title: Perioperative Haemostasis, Procedure-Related Pain After Physiological or Pharmacological Modifications of Local Anaesthesia Around the Eyes (P4LE) - a Double-Masked, Split-Face, Active-Controlled, Pilot Randomised Clinical Trial
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
80
Start Date
2026-08
Completion Date
2028-07
Last Updated
2026-08-03
Healthy Volunteers
No
Interventions
Sodium Bicarbonate (NaHCO3)
Lignocaine buffered with sodium bicarbonate
Warmed lignocaine
Lignocaine warmed to body temperature
Hyaluronidase Injection
Lignocaine with hyaluronidase added
Tranexamic Acid (TXA)
Lignocaine with tranexamic acid added
Lignocaine 2% concentration solution
2% lignocaine with 1:200,000 adrenaline
Locations (3)
Alice Ho Miu Ling Nethersole Hospital
Hong Kong, Hong Kong
CUHK Medical Centre
Hong Kong, Hong Kong
Prince of Wales Hospital
Hong Kong, Hong Kong