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NOT YET RECRUITING
NCT07734740
PHASE3

Perioperative Haemostasis, Procedure-Related Pain After Physiological or Pharmacological Modifications of Local Anaesthesia Around the Eyes

Sponsor: Prince of Wales Hospital, Shatin, Hong Kong

View on ClinicalTrials.gov

Summary

The goal of this clinical trial is to determine whether buffering, warming, or addition of hyaluronidase or tranexamic acid to lignocaine during eyelid injection of local anaesthesia reduce injection pain and procedure-related pain and improve perioperative haemostasis.

Official title: Perioperative Haemostasis, Procedure-Related Pain After Physiological or Pharmacological Modifications of Local Anaesthesia Around the Eyes (P4LE) - a Double-Masked, Split-Face, Active-Controlled, Pilot Randomised Clinical Trial

Key Details

Gender

All

Age Range

18 Years - Any

Study Type

INTERVENTIONAL

Enrollment

80

Start Date

2026-08

Completion Date

2028-07

Last Updated

2026-08-03

Healthy Volunteers

No

Interventions

DRUG

Sodium Bicarbonate (NaHCO3)

Lignocaine buffered with sodium bicarbonate

DRUG

Warmed lignocaine

Lignocaine warmed to body temperature

DRUG

Hyaluronidase Injection

Lignocaine with hyaluronidase added

DRUG

Tranexamic Acid (TXA)

Lignocaine with tranexamic acid added

DRUG

Lignocaine 2% concentration solution

2% lignocaine with 1:200,000 adrenaline

Locations (3)

Alice Ho Miu Ling Nethersole Hospital

Hong Kong, Hong Kong

CUHK Medical Centre

Hong Kong, Hong Kong

Prince of Wales Hospital

Hong Kong, Hong Kong